![]() ![]() Mitch, in Therapy in Nephrology & Hypertension (Third Edition), 2008 Amino Acid SolutionsĪmino acid solutions containing exclusively essential amino acids should no longer be used. ![]() The amplitude of these diurnal changes in the rates of protein synthesis and degradation appears to vary in direct proportion to the amount of protein which an individual habitually consumes. In nongrowing adults these changes balance out over a 24-h period, so that there is no net change in body protein content. Subsequently, in the postabsorbtive state these changes in the rates of protein synthesis and breakdown are reversed, so that there is net release of amino acids from protein. Protein degradation is suppressed following a meal containing protein, and the rate of protein synthesis may be increased, so that there is net storage of amino acids as protein. There is some evidence that the rates of protein synthesis and degradation are regulated by amino acid supply and that this is another homeostatic mechanism acting to maintain free amino acid concentrations within safe limits. The concentrations of free amino acids are regulated largely by modulation of their catabolic pathways, though in the case of nonessential amino acids there is also some regulation of the rate at which they are synthesized. Emery, in Encyclopedia of Human Nutrition (Third Edition), 2013 Amino Acid Poolsįree amino acids make up only approximately 2% of the total amino acid content of the body, the rest being present as protein. ![]()
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